Abstract

Oxidative stress-induced pancreas damage is a key event in beta cell impairment and diabetes development. Catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) are three important cellular antioxidant enzymes protecting the pancreas against oxidant insult. The present study examines the protective capabilities of Cellgevity® (a popular poly-antioxidant supplement) on pancreas oxidative stress parameters. Diabetes was induced by streptozotocin (STZ) intraperitoneal intoxication (55 mg/kg) in adult male Wistar rats. Control and diabetic untreated (DM-untreated) groups received distilled water, diabetic treated 1 group (DM-treated 1) received Cellgevity® (25 mg/kg body weight) and Diabetic treated 2 (DM-treated 2) group received Cellgevity® (40 mg/kg body weight) for twenty-eight days, respectively. The results show that diabetes in DM-untreated significantly increased ........................